Juventus depend on Dusan Vlahovic and Federico Chiesa, as Frosinone play Juve-owned Matias Soulé and Walid Cheddira.
It kicks off on the Allianz Juventus Stadium at 11.30 GMT.
You possibly can comply with all of the build-up and motion because it occurs from right now’s 4 Serie A video games on the LIVEBLOG.
The Bianconeri are hanging on to second place regardless of managing simply two factors from 4 rounds, together with a house defeat to Udinese and 2-2 draw at Verona.
Gleison Bremer returns from suspension, however Danilo joins Moise Kean, Mattia De Sciglio and Mattia Perin on the remedy desk.
Max Allegri examined out a 4-3-3 formation in coaching, however sticks to 3-5-2 right here with Chiesa becoming a member of Vlahovic upfront.
There have been rumours that Carlos Alcaraz, who arrived in January on mortgage from Southampton, would begin, however as an alternative Fabio Miretti can also be on the bench with Weston McKennie moved to a extra central function.
Frosinone are struggling too, coming off three consecutive defeats to Milan, Fiorentina and Roma.
Kevin Bonifazi, Riccardo Marchizza, Anthony Oyono, Mateus Lusuardi, Sergio Kalaj, Marvin Cuni and Giuseppe Caso are out of motion.
Kaio Jorge, Soulé and Enzo Barrenechea are all on mortgage from Juventus, however solely the Argentine ahead begins in opposition to their mother or father membership.
Eusebio Di Francesco makes just a few stunning changes, dropping Kaio Jorge in favour of Walid Cheddira, with Emanuele Valeri in a extra superior function.
Juventus: Szczesny; Gatti, Bremer, Rugani; Cambiaso, McKennie, Locatelli, Rabiot, Kostic; Vlahovic, Chiesa
Frosinone: Cerofoloni; Lirola, Romagnoli, Okoli, Zortea; Brescianini, Mazzitelli, Harroui; Valeri, Soulè, Cheddira